Author(s): Paolo Zatta
Metallothioneins (MTs) constitute a big circle of relatives of proteins characterised by way of top heavy steel content material (basically CuII and ZnII) and by way of an ordinary cysteine abundance. They have an impressive protecting serve as in all animal tissues, due perhaps to their houses as unfastened radical scavengers protective towards oxidative injury. Moreover, the presence and overexpression of MTs in quite a lot of pathological stipulations, akin to steel dyshomeostasis, mobile proliferation, neurological issues, and chemotherapy and radiotherapy resistance, might be used as a very powerful prognostic marker, as a histopathological diagnostic device, and to apply explicit pharmacological remedies.This essential guide explores the position of MTs within the box of neurological issues (mind irritation, Alzheimer’s and prion illnesses, autism, ALS, and so on.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast most cancers), thru authoritative contributions and an outline of elementary biochemical knowledge and paradigmatic pathological occasions.