Author(s): Novartis Foundation
Several basically necessary questions shape the foundation for this e-book. What are the relationships between tumour formation and tumour pH? What are the results of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the healing penalties of tumour pH? It is hypothesised that low extracellular pH is not just a very powerful end result of tumour expansion however might also advertise additional tumorigenic transformation. Furthermore, in vitro research recommend that low pH strongly impacts the efficacy of chemo- and radiotherapy. Better working out of the affect of pH on tumour expansion, coupled with manipulation of the pH of the tumour microenvironment, would possibly result in the improvement of more practical treatments.