Author(s): Novartis Foundation
Several essentially essential questions shape the foundation for this guide. What are the relationships between tumour formation and tumour pH? What are the results of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the healing penalties of tumour pH? It is hypothesised that low extracellular pH is not just a very powerful outcome of tumour enlargement however might also advertise additional tumorigenic transformation. Furthermore, in vitro research recommend that low pH strongly impacts the efficacy of chemo- and radiotherapy. Better figuring out of the affect of pH on tumour enlargement, coupled with manipulation of the pH of the tumour microenvironment, might result in the advance of more practical remedies.